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Branched-chain amino acids, leucine, isoleucine, and valine, when present in adequate concentrations, are supposed to maintain plasma glutamine concentration and cytokine (interleukin-1) production, while attenuating lymphocyte proliferation. This corresponds to maintaining the integrity of the immune system. Cytokines regulate immune and inflammatory responses and glutamine maintains skeletal muscle protein when the body's need for glutamine exceeds its natural production.
Prolonged, exhaustive exercise may cause the activity of the immune response cells to be suppressed. During such periods of metabolic stress, increasing the amount of glutamine made available would increase protein synthesis, maintain glutamine production, thereby maintaining activity of the immune response cells. If glutamine is not available, muscle catabolism (degradation, breakdown) proceeds and reductions in plasma glutamine concentration are likely, leaving the body's immune system more susceptible to invasion.
BCAAs also compete with tryptophan for transport across the blood-brain barrier. If tryptophan wins, it is converted to 5-hydroxytryptomine, leading to an increase in serotoninergic neurotransmitter activity. It is well known that serotonin-like activity causes central fatigue (the "Central Fatigue Theory"). Theory has it that if BCAAs are present in concentrations high enough to win the BCAA-tryptophan battle, BCAAs could reduce the exercise-induced tryptophan uptake by the brain, thus delaying fatigue. This would allow the athlete to continue to perform.
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Whilst researching health and fitness qualifications I found that the ISSA was among the most competitive and offered the most for the money.
I have no complaints and I will always proudly display my certification and recommend you to all I know. You have given me a foundation for my future.
Walter Sadiq Daniels
I'm so proud to be an ISSA Certificate Trainer because I know I have one of the best and most complete foundations for those who trust me to help transform their physiques and begin living a healthy lifestyle.
ISSA has brought a strong root into my life that keeps leading me towards success.
During the process of certification, I was able to redesign my fitness approach and started creating my own plans...
Jorge De La Rosa
I would like to say that the course l've attended _CFT_ was very useful and I feel that my techniques are better and my clients are more blessed and satisfied.
Mostafa Mahmoud El Gindy
The ISSA gave me a great knowledge of fitness programming, movement screening and nutrition.
This is something I am proud of, not only in my personal accomplishments, but in being able to help others do the same.
ISSA definitely proved themselves above and beyond. I definitely received more than I expected and absolutely excited to take more courses.
Did my research and found out that not only is ISSA a reputable certification, they also are willing to help you succeed after you get certified.
Joseph Alexander Harris
ISSA helped to guide me down the path toward an exciting future in the fitness industry!
I learned so much about what it takes to be a trainer. The program covers tons of information, but it was manageable and very useful and relevant.
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